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在北極地區(qū)，白鯨(Delphinapterus leucas)是高等級(jí)捕食者，可能作為哨兵物種，可能預(yù)測(cè)對(duì)人類健康的影響。雖然血液轉(zhuǎn)錄組的基因表達(dá)譜已被廣泛用于評(píng)估人類和獸醫(yī)的健康狀況和環(huán)境暴露

當(dāng)細(xì)胞失去控制時(shí)，癌癥就會(huì)出現(xiàn)。解讀癌細(xì)胞的“藍(lán)圖” - 概述癌細(xì)胞如何劫持特定途徑以實(shí)現(xiàn)不受控制的擴(kuò)散 - 將導(dǎo)致更有效的方法來(lái)對(duì)抗它。來(lái)自魏茨曼科學(xué)研究所的科學(xué)家和來(lái)

While the amount of small non-coding RNA sequencing data is continuously increasing, it is still unclear to which extent small RNAs are represented in the human genome. Saarland University researchers have analyzed 303 billion sequencing rea

雖然小的非編碼RNA測(cè)序數(shù)據(jù)的數(shù)量不斷增加，但仍然不清楚小RNA在人類基因組中的代表程度。薩爾大學(xué)的研究人員已經(jīng)分析了來(lái)自近25,000個(gè)數(shù)據(jù)集的3030億個(gè)測(cè)序讀數(shù)來(lái)回答這個(gè)問(wèn)題。

While many cells in our bodies can accumulate oncogenic mutations, the majority of these events do not lead to tumor formation as these abnormal cells are eliminated by defense mechanisms. Instead, tumors arise when a mutation happens in a p

雖然我們體內(nèi)的許多細(xì)胞可以積累致癌突變，但這些事件中的大多數(shù)不會(huì)導(dǎo)致腫瘤形成，因?yàn)檫@些異常細(xì)胞被防御機(jī)制消除。相反，當(dāng)突變發(fā)生在對(duì)其特異性敏感的特定細(xì)胞類型中時(shí)

單細(xì)胞mRNA測(cè)序(scRNA-seq)允許分析異質(zhì)細(xì)胞群，提供解決各種生物和醫(yī)學(xué)問(wèn)題的令人興奮的可能性。最近開(kāi)發(fā)了一系列方法，因此有必要系統(tǒng)地比較它們的靈敏度，準(zhǔn)確度，精度和成本效

Single-cell mRNA sequencing (scRNA-seq) allows to profile heterogeneous cell populations, offering exciting possibilities to tackle a variety of biological and medical questions. A range of methods has been recently developed, making it nece